Conference
Programme
Sunday 16 February
Name badge pick up
3.00pm
Welcome Reception
Te Pae Christchurch Convention Centre
5.00 - 6.30pm
Monday 17 February
Registrations open
8.00am
Welcome and mihi whakatau
9.00am
Keynote Address by Malcom White | Chair: Dipali Sashital
Malcolm White
The diversity and regulation of type III CRISPR systems
9.30am
MORNING TEA
10.20am
RNA-targeting CRISPR | Chair: Tina Liu
Doreen Addo-Yobo
A CRISPR-associated Rossman-fold Ring Nuclease and Adenosine Deaminase Fusion Allosterically Converts ATP to ITP
10.50am
Naama Aviram
Cas10 nuclease activity relieves host growth arrest to facilitate spacer retention during type III-A CRISPR immunity
11.10am
Mohamed Fareh
The molecular basis of target recognition and cleavage by CRISPR-Cas13
11.30am
Mitch O'Connell
Pulling the Plug on Bacteriophage Infection: The Pore Behavior of Membrane Proteins that Reside Within RNA-Targeting CRISPR-Cas and other Antiphage Defense Systems
11.50am
LUNCH
12.30pm - 1.00pm LUNCH AND LEARN SESSION WITH EDILYTICS | Overcoming Challenges in Genome Editing Analysis
Grab lunch and explore common challenges in genome editing analysis and discover how CRISPResso can support your research. This session includes a live demo of Prime Editing analysis and an interactive Q&A to enhance your genome editing workflows.
12.10pm
anti-CRISPR (1) | Chair: Karen Maxwell
Nicole Marino
Translation-dependent downregulation of Cas12a mRNA by an anti-CRISPR protein
1.30pm
Alan Davidson
Structures and Mechanisms of Type I-E anti-CRISPRs Elucidated Using a New E. coli CRISPR-Cas System
1.50pm
Katharina Wandera
AcrVIB1 turns Cas13b into a crRNA trap
2.10pm
Ryan Catchpole
Invaders and evaders from the deep!
2.30pm
AFTERNOON TEA
2.50pm
anti-CRISPR (2) | Chair: Hong Li
Joe Bondy-Denomy Gabija is activated by a phage DNA recombination system that antagonizes CRISPR
3.20pm
Yan Zhang
An unbiased de novo Acr discovery approach uncovered novel anti-CRISPR mechanisms by Neisseria filamentous phage
3.40pm
Lightning Talks
4.00pm
Poster Session
4.30pm
Day one concludes
6.30pm
Free evening to relax, or explore the city
Tuesday 18 February
Registrations open
8.00am
Adaptation | Chair: Ivana Ivančić-Baće
Joshua Modell
Temperate phages facilitate CRISPR-Cas immunizations through diverse mechanisms
9.00am
Alexander Meeske
Crosstalk between three CRISPR-Cas types enables primed type VI-A adaptation in Listeria seeligeri
9.20am
Ugne Gaizauskaite
Prespacer selection by the Type II-A Cas9-Cas1-Cas2-Csn2 Holo-Complex in CRISPR-Cas adaptation
9.40am
10.00am
Class 2
Oleg Dmytrenko
CRISPR-Cas12a3 confers immunity through tRNA inactivation
MORNING TEA
10.00am
Class 2 | Chair: Ryan Jackson
Chase Beisel
Exploring and harnessing the functional diversity of CRISPR-Cas12a2 nucleases
10.30am
10.50am
Class 2
Oleg Dmytrenko
CRISPR-Cas12a3 confers immunity through tRNA inactivation
Grace Hibshman
Mechanism of type II-B CRISPR-Cas enhanced specificity
11.10am
Yanli Wang
An R-loop-dependent RNase: structural basis for the inhibition of Cas9 by AcrIIA5
11.30am
Florian Hoffmann
RNA-guided gene activation via RNA polymerase recruitment by Cas12f-Sigma factor complexes
11.50am
LUNCH
12.10pm
Technology (1) | Chair: Marc Güell
Sponsored by Iowa State University - Crop Bioengineering Center
Ailong Ke
Less is more: Converting IscB to a versatile RNA-guided RNA editing tool by switching off its DNA-binding activity
1.30pm
Jun-Jie (Gogo) Liu
RNA and Gene-editing
1.50pm
Cameron Myhrvold
CRISPR-based technologies for multiplexed nucleic acid detection
2.10pm
Fei Deng
Modulating Cas13a trans-cleavage by double strand RNA: Application to the development of an autocatalytic sensor
2.30pm
AFTERNOON TEA
2.50pm
Technology (2) | Chair: Jacob Corn
Srishti Sahu
Electroporation-free delivery of CRISPR enzymes for efficient genome editing of primary human immune cells
3.20pm
Hilary Longhurst
In vivo CRISPR/Cas9 gene editing of KLKB1in patients with hereditary angioedema (C1 inhibitor deficiency)
3.40pm
Poster Session
4.00pm
Day two concludes
6.00pm
Conference Dinner
Christchurch Art Gallery Te Puna o Waiwhetū
7.00pm
Wednesday 19 February
Registrations open
8.00am
Ecology/Evolution | Chair: Bridget Watson
Feng Zhang (presenting virtually)
Exploration of Biological Diversity
9.00am
Sean Meaden
Environmental distributions of CRISPR and defence systems across environments
9.20am
Kepler Mears
TnpB enables the intracellular gene drive of IS200/605 transposons in plasmids
9.40am
Shai Zilberzwige Tal
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxin
10.00am
MORNING TEA
10.20am
CASTs and ecosystems | Chair: Sibylle Vonesch
Elizabeth Kellogg
Efforts to understand and engineer CAST for improved activity/specificity
10.50am
Diego Gelsinger
Metagenomic editing using CASTs enables genetic access to diverse and unculturable bacteria in the gut microbiome
11.10am
Agnes Oromi-Bosch
Self-selecting systems for CAST-based microbiome editing
11.30am
Bruria Samuel
Plasmids Fight Back: Anti-Defense Systems Boost Conjugation Efficiency
11.50am
LUNCH
12.10pm
Beyond CRISPR (1) | Chair: Jack Bravo
Blake Wiedenheft
CRISPRs, anti-CRISPR, and ATP-driven sensors that trigger translational arrest
1.30pm
Ming Li Multilayered CRISPR Defense and Anti-CRISPR Counteraction
1.50pm
Monika Jasnauskaite
Structure and mechanisms of retron Ec67
2.10pm
Giovanni Leandri
Insights into Azaca: a novel widespread antiphage defence system
2.30pm
Bruce Wang
Discovery of transcriptionally regulated anti-phage defence systems with single-cell massively-parallel multiplexed microbial sequencing (M3-seq)
2.50pm
AFTERNOON TEA
3.10pm
Beyond CRISPR (2) | Chair: Inga Songailiene
Asma Hatoum-Aslan
Anti-phage defenses in staphylococci
3.40pm
Ning Jia
Mechanistic insights into reverse transcriptases in anti-phage defense
4.00pm
EMBO Young Investigator Lecture
Aude Bernheim
Evolution of immunity across domains of life
4.20pm
Distinguished Lecture by John can der Oost | Chair: Mike Terns
John van der Oost
CRISPR-Cas - from Evolution to Revolution
4.40pm
Closing comments
5.20pm
Scientific program concludes
5.30pm
Thursday 20 February
Optional day trip to Akaroa
8.00am - 4.30pm